Organic chemist
Chembind Glycoscience LLC
The organic synthesis division is seeking several energetic and self-motivated individuals to join our team as a chemist to especially in carbohydrate synthesis to produce structure-defined oligosaccharides and glycolipids, sugar nucleotides and their derivatives, carbohydrate-based pharmaceuticals. The individual in this position will also work as a member of the production team responsible for a diverse line of products.
Link:
www.chembind.com
Post doc
University of Copenhagen
The Halim, Miller and Schjoldager groups are offering one or more post doc positions at the Copenhagen Center for Glycomics (CCG) commencing from 1 January 2023 or later in 2023. For more info see link below.
Link:
https://www.nature.com/naturecareers/job/postdoc-in-functional-analysis-of-glycoproteins-and-glycosaminoglycans-at-copenhagen-center-for-glycomics-ccg-at-the-department-of-cellular-and-molecular-medicine-icmm-university-of-copenhagen-ucph-762579
Project Manager
i3S- University of Porto
Applications are open from September 28 to October 12 for a PhD position on a fixed-term contract to perform project management functions within the project “ GLYCANS AS MASTER TRIGGERS OF HEALTH TO INTESTINAL INFLAMMATION TRANSITION” in the Immunology, Cancer & GlycoMedicine group at i3S In University of Porto, Portugal (https://www.i3s.up.pt/research-group.php?groupid=122). We are looking for a project manager (GP) who will play a central role in the management of a EU-funded project and will be an integral member of the project team.
Link:
Full announcement: https://bit.ly/3xXp5lU
Postdoctoral Researcher
Emory University School of Medicine
Two postdoctoral associate positions are available in the laboratory of Dr. Fikri Avci for NIH-supported projects. Avci Lab moved to Emory University School of Medicine in July 2022 as a member of the Department of Biochemistry and Emory Vaccine Center.
Avci Lab is an interdisciplinary research group with an objective to explore the treatment of and protection from infectious diseases and cancer by understanding key molecular and cellular interactions between the components of the immune system and carbohydrate antigens associated with pathogens, symbionts, or cancers. The projects will focus on, but not be limited to, the molecular and cellular basis for activation or regulation of immune responses by bacterial, viral, or cancer-associated carbohydrate antigens. Successful candidates will have the opportunity to learn and apply immunological and biochemical tools, as well as wirking with in vivo animal models and human specimens to study key mechanisms by which carbohydrate antigens induce immune responses.
Emory University offers a highly collaborative, top-notch training and research environment in biomedical sciences. The Department of Biochemistry is a leading research division at Emory University School of Medicine. Emory Vaccine Center is one of the largest academic vaccine centers in the world. Expertise at the Emory Vaccine Center spans the disciplines of basic immunology, infectious diseases, biodefense pathogens, and cancer immunology.
Interested candidates should email their Curriculum vitae, a short letter of interest outlining experience and research goals, and the names and contact information of three references to: favci@emory.edu
Link:
None
Associate scientist
A new stealth and growing biotech company
Associate Scientist, Synthetic Chemistry
Seeking a highly motivated, talented, and innovative Associate Scientist to join our team. They will contribute their expertise in synthetic chemistry and analytical method development for biomolecule chemo-enzymatic synthesis, and conjugation and purification of conjugates. The successful candidate will play a lead role in construction, purification and qualification in support of our early phase drug development programs for our novel platform technology.
About GanNA
Founded in September 2021 by Dr. Ryan Flynn (BCH/Harvard) the discoverer of Glyco-RNA and expert in RNA biology, and Drs. Rick Cummings (BIDMC/Harvard), and Carolyn Bertozzi (Stanford), who are world-experts in glycobiology and glyco-chemistry, our new stealth company was launched last year to harness the potential biology of glyco-RNAs for delivery and immune modulation. Our newco is funded by a larger platform company that holds significant domain expertise across RNA delivery, manufacturing, chemistry, and DMPK. The founding team of this parent company has previously built Elevate Bio, Orna and has committed to a large Series A financing.
Responsibilities
• Develop and optimize chemical conjugation
• Chemoenzymatic synthesis
• Manage/Perform method development, optimization, qualifications, and validations
• Develop new test methods for the characterization of purity and potency of cell-based intermediates and drug product
Qualifications:
• Master in organic chemistry, analytical chemistry, or related field
• Previous experience with carbohydrate chemistry is a plus
• Previous experience with HPLC system and LC-MS is a plus
• Previous experience with glycobiology is a plus
Postdoctoral Fellowship - Protein Expression and Modification Research
New England Biolabs
A Postdoctoral Fellow position is available in the laboratory of Dr. Christopher Taron in analytical glycobiology. The proposed work aims to study newly discovered enzymes that generate glycopeptides or that act upon chemical modifications of glycans (e.g., sulfation). A primary focus will be on understanding the specificities and biochemical properties of new enzymes discovered from environmental screening. Additional work will apply interesting specificities to analytical workflows (e.g., glycomics, glycoproteomics, or MALDI imaging) to improve the analysis of glycans/glycoproteins in the context of complex biological samples. The research will be done in collaboration with our high-throughput enzyme discovery team and our protein mass spectrometry team.
The ideal candidate will:
- Have research experience in glycobiology, preferably working with free-glycans and/or glycopeptides
- Have hands-on experience in molecular biology, protein expression and biochemical characterization of proteins
- Be familiar with current glycomics and glycoproteomics techniques
- Have excellent interpersonal skills and ability to work as part of a large multidisciplinary team
- Be able to lead a basic research project that spans multiple technical disciplines
Qualifications:
- A doctorate in analytical chemistry, biochemistry, or related field
- A strong record of scientific publication
- Excellent verbal and written communication skills
This position offers exciting opportunities for broad research training, collaboration with academic institutions, publishing in peer-reviewed journals and participation in national and international conferences.
Link:
https://neb.wd5.myworkdayjobs.com/en-US/NEB_Careers/job/Ipswich-MA-United-States/Postdoctoral-Fellowship---Protein-Expression-and-Modification-Division_1441
Postdoctoral Fellow
FDA
The Laboratory of Bacterial Polysaccharides (DBPAP/OVRR/CBER) is searching for a postdoctoral fellow to perform structural studies on bacterial polysaccharide fragments (OSs) and their interactions with antibodies, with the aim of improving our understanding of the OSs’ “active” conformations. The candidate should have extensive experience with analytical methods and a strong background in quantitative analysis. Solution NMR background is preferred. Experience in microbiology, biochemistry and MS are pluses. A Ph.D. is required with less than three years’ experience. The position is available immediately. Please, send a resume and three letters of recommendation to Dr. Marcos Battistel, email: marcos.battistel@fda.hhs.gov.
More about us: LBP is a collaborative multidisciplinary group that focuses on four major subjects: Cellular immunology, epidemiology, biochemistry and structural biology. As the structural biology group, our main research tools are NMR instruments (500, 700, 850 MHz), CD, ITC, SEC-MALS, MS and access to electron microscopes. LBP is on the FDA main campus and is within 25 miles of NIH, NIST and the I-270 tech corridor.
Postdoctoral Fellow
Children's Hospital of Philadelphia
The congenital disorders of glycosylation (CDG) are a group of rare genetic disorders that disrupt the cellular glycosylation machinery. Affected patients exhibit severe neurological deficits. Despite being an essential post-translational modification, the roles of glycosylation in protein function are highly complex and remain poorly understood. The genetic basis of CDG provides an opportunity to identify the neurobiological functions of glycosylation using mouse models and glycoproteomics. In tandem, an understanding of glycosylation in the nervous system will help to elucidate the pathophysiology of CDG, enabling therapeutic advances.
Dr. Andrew Edmondson is an enthusiastic new PI who seeks a postdoctoral fellow to help uncover the molecular mechanisms underlying dysfunctional glycosylation in mouse and cellular models of CDG. The successful candidate will be self-motivated and hard-working, with strong molecular biology skills (Western blot, qPCR, cell culture), as well as prior experience working with mice or glycoproteomics and an experimental background in glycobiology or neuroscience. The postdoctoral fellow will be responsible for their own research project investigating a specific human genetic disease of dysfunctional glycosylation (i.e., CDG). Work will largely focus on molecular investigations in tissues and cells derived from mice and affected human patients. Transformative discoveries in basic and translational glycobiology are anticipated.
Interested and qualified individuals should submit their resume to Andrew Edmondson, MD, PhD (edmondsona@chop.edu)
Research Technician
Children's Hospital of Philadelphia
The congenital disorders of glycosylation (CDG) are a group of rare genetic disorders that disrupt the cellular glycosylation machinery. Affected patients exhibit severe neurological deficits. Despite being an essential post-translational modification, the roles of glycosylation in protein function are highly complex and remain poorly understood. The genetic basis of CDG provides an opportunity to identify the neurobiological functions of glycosylation using mouse models and glycoproteomics. In tandem, an understanding of glycosylation in the nervous system will help to elucidate the pathophysiology of CDG, enabling therapeutic advances.
Dr. Andrew Edmondson is an enthusiastic new PI who seeks a research technician to help uncover the molecular mechanisms underlying dysfunctional glycosylation in mouse and cellular models of CDG. The successful candidate will be self-motivated and hard-working, with strong molecular biology skills (Western blot, qPCR, cell culture), as well as prior experience working with mice or glycoproteomics.
Interested and qualified individuals should submit their resume to Andrew Edmondson, MD, PhD (edmondsona@chop.edu)
2 Tenure Track Asst/Assoc Professor Position in Glycoscience at CCRC
CCRC at UGA
The University of Georgia announces openings for two tenure track faculty members at the Assistant or early Associate Professor level in the Complex Carbohydrate Research Center in any area of biomedical, microbial, or plant glycoscience. Please apply at https://www.ugajobsearch.com/postings/280494. In addition to your curriculum vitae, please provide a cover letter, a 2-page detailed research plan, and a 1-2-page teaching statement as a single pdf document. Also, please provide complete contact information (email, address and phone) for three individuals of reference. Please include discussion of your commitment to mentorship and fostering a diverse and inclusive learning environment in the classroom and in your research group within the application materials. Questions for the Search Committee may be directed to Anna Bighta (Anna.Bighta@uga.edu). Completed applications received by November 28, 2022, are assured full consideration. The University of Georgia is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, ethnicity, age, genetic information, disability, gender identity, sexual orientation or protected veteran status.
Link:
https://www.ugajobsearch.com/postings/280494
Glycobiology Fellowships
Johns Hopkins University
We are looking for M.D., Ph.D., and M.D./Ph.D. scientists interested in glycans to participate in our K12 program - Immersive Training in the Glycosciences. Projects will be broadly related to: Firstly) the role of O-GlcNAc in injury and in the pathophysiology of disease; Secondly) Immune regulation in airway diseases; Thirdly)
Applicants must be citizens or non-citizen nationals of the United States or have been lawfully admitted for permanent residence at the time of appointment. At the time of appointment scholars should hold an M.D. and/or Ph.D. degree.
Link:
https://glycocareers.cclinic.jhu.edu/
Postdoctoral Fellow at the University of Michigan
University of Michigan
Research in the Wang Lab focuses on the biogenesis, function, and defects of the Golgi in diseases. The Golgi apparatus is a central membrane organelle for protein trafficking, glycosylation, and secretion in all eukaryotic cells. A unique feature of this organelle is a stack of flattened cisternae. Our research aims to understand how this structure is formed, why its formation is important for Golgi function under normal conditions, and how the Golgi becomes defective in its structure and function under stress or disease conditions. The work will provide a basic understanding of Golgi function in protein trafficking, glycosylation, inheritance during the cell cycle, and pathology in diseases such as cancer and Alzheimer’s disease. For reference please go to our website at: https://sites.lsa.umich.edu/wang-lab/.
The successful candidate should be a recent Ph.D. graduate with experience in cell biology, protein biochemistry, molecular biology, and light and electronic microscopy, with a record of creativity and scientific productivity.Please provide curriculum vitae, a brief summary of research accomplishments and future goals, and the names and contact information of three references to: Dr. Yanzhuang Wang, LSA Department of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 North University Avenue, Ann Arbor, MI 48109-1085. E-mail directly to yzwang@umich.edu with subject line POSTDOC.
Link:
https://sites.lsa.umich.edu/wang-lab/
Lab Technician
NatGlycan LLC
NatGlycan, LLC is seeking Lab technicians with experience in High Performance Liquid Chromatography (HPLC) for analytical and preparative scale isolation of oligosaccharides (glycans) from natural sources. The successful candidate will be able to follow documentation systems found in the Quality Manual, SOPs, Local Work Instructions and Methods for the manufacture of purified glycans for sale to the research community. This individual needs to maintain records of the results of all testing procedures and input results into computer and/or log books on a daily basis in order to document test results. Minimum requirements are a High School diploma or equivalent with some laboratory experience, but preference will be given to individuals with an Associate, Bachelor’s, or Master’s degree in a relevant science. The position will require good oral and written communication skills, ability to follow laboratory safety regulations and familiarity with computers, including current commercial software applications such as Excel and Word.
Essential Duties and Responsibilities
• Regular attendance and punctuality
• Reads, understands, and follows management system requirements as relevant to responsibilities, including but not limited to requirements found in the Quality Manual, SOPs, Local Work instructions and Methods
• Perform various routine laboratory functions in a precise and accurate fashion, to assist the laboratory professional staff and to facilitate production
• Identify process difficulties and report these together with proposed solutions to supervisor
• Performs analytical testing using instrumental, wet chemistry procedures, and records results in computerized data systems.
Link:
http://NatGlycan.com
A Postdoctoral Position at New England Biolabs
New England Biolabs
We are seeking a talented, highly motivated researcher to join the Protein Expression and Modification Division at New England Biolabs as a postdoctoral fellow. The successful candidate will primarily focus on discovery, engineering and characterization of protein-modifying enzymes and enzymes for glycobiology research.
Primary responsibilities:
• Establish and optimize a microdroplet enzyme screening workflow which is compatible with in vitro protein synthesis reactions and cell-based metagenomic library screening.
• Develop assays suitable for microdroplet screening and metagenomic library screening.
• Utilize the microdroplet screening system to discover/engineer enzymes with the primary focus on protein-modifying enzymes or glycoenzymes.
• Characterize the discovered/engineered enzymes and apply them in proteomics or other analytical workflows.
• Effectively communicate the discoveries to the scientific community through presentations and peer-reviewed publications.
Required Qualifications and Experience:
• PhD in Biochemistry, Molecular Biology, Chemistry or related field.
• Advanced skill level in molecular biology and protein biochemistry techniques.
• Strong multitasking ability.
• Excellent verbal and written communication skills
• A strong work ethic with an emphasis on both efficiency and quality of work.
• Proven ability to work independently and in collaborative team environments.
Preferred Qualifications and Experience:
• Experience with microdroplet screening or metagenomic library screening.
• Experience with FACS Flow Cytometry is a plus.
• Experience with protein evolution.
• Knowledge with bioinformatics or protein structure is also a plus.
This position offers exciting opportunities for research training in an industrial setting, collaboration with academic institutions, publishing in peer-reviewed journals and participation in meetings and conferences.
Link:
https://neb.wd5.myworkdayjobs.com/en-US/NEB_Careers/details/Postdoctoral-Fellowship--Protein-Expression---Modification-Division_1509
