Postdoctoral Fellow /Senior Scientist: Schwannoma Merlin Biology
University of Central Florida (UCF)
In the laboratory of Dr. Cristina Valle in the College of Medicine at the University of Central Florida in Orlando, FL.
Postdoctoral Research Associate
Washington University
The Gutmann Laboratory is seeking talented and highly motivated postdoctoral researchers to work on several exciting new projects using human induced pluripotent stem cell (hiPSC) and novel genetically engineered mice to investigate how neurons and immune system cells control brain formation and progression (Guo X, Nature Communications 2020; Pan Y Nature 2021; Chatterjee J, Nature Communications 2021; Anastasaki C, Nature Communications 2022).
Postdoctoral researchers will have the opportunity to work on independent projects in a very energetic and passionate laboratory, with the potential to collaborate with numerous other investigators, both at Washington University and internationally. Importantly, the project is specifically designed to enable trainees to employ these platforms to establish their future research laboratories. In addition to state-of-the-art research facilities and highly invested scientific mentorship, further career and professional development training for postdoctoral researchers is provided through the Neurofibromatosis Center (https://nfcenter.wustl.edu), the Hope Center (https://hopecenter.wustl.edu/), and the Office of Postdoctoral Affairs at Washington University.
Additional information on becoming a postdoctoral research trainee at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs.
Qualifications include a PhD degree in neuroscience, immunology, oncology, or a related field. Experience with standard molecular and cell biology methodologies is preferred. Interested candidates should send a cover letter and updated curriculum vitae to David H. Gutmann, MD, PhD (gutmannd@wustl.edu).
Link:
http://gutmannlab.wustl.edu
Sr. Scientist
Infixion Bioscience, Inc.
WHO WE ARE
Infixion Bioscience is an early-stage drug discovery company looking for novel therapies to treat Neurofibromatosis (NF1). We are based on San Diego, CA, and have received three Phase 1 SBIR grants to date. With several discovery pipelines in motion, we are focused on an innovative approach for treating this rare, autosomal dominant, haploinsufficient disease. This is a true start-up effort, with a small team --- and limited infrastructure.
WHAT WE ARE LOOKIN FOR
We are looking for a highly motivated (hands-on) cellular and molecular biologist to hit the ground running, taking over the design and execution of select discovery pipelines. The successful candidate will have a strong understanding of standard molecular biology and cell biology techniques to allow for planning, execution, troubleshooting, and subsequent analysis of data generated. You will manage vendors, collaborators, and supplies purchasing. You may be asked to write grants, publications, and/or patent applications. Effective communication will be key to providing a flow of information on progress, results, and bottlenecks to facilitate data analysis and continuous reprioritization. We are a small group, and this is a hands-on lab position. You will be expected to wear many hats, and be flexible to contribute wherever the need arises. Ideal for the entrepreneur scientist.
SPECIFIC SKILLS WE ARE LOOKING FOR
• Assay Development: adapting assays for HTS-like screening, optimizing screening conditions for drug testing and follow up
• Cell Biology: routine cell culture maintenance, CRISPR editing and identification, manipulation of cells (siRNA, plasmid delivery, lenti or adeno)
• Molecular Biology: western blots, qCPR, in-cell westerns, ELISAs, MSD, etc.
• Writing/Presenting: Data analysis, grant applications, publications, management communications, etc.
• Nice to have: NF1 experience, in vivo drug discovery, neuroscience, IPSC culture, biomarker discovery.
Link:
https://www.infixionbio.com
Data Analyst (Marketing and Business Insights
Children's Tumor Foundation
The Children’s Tumor Foundation (CTF) is seeking a smart and motivated data-minded and marketing/business insights superstar for a key Foundation role that impacts CTF’s core business activities (revenue, marketing, and finance). It is a unique opportunity to not only improve and build upon how data comes into the Foundation and is used in support of Foundation goals, but to contribute to the growth of the Foundation through the development of tools, dashboards, and analysis that improve efficiencies, expand knowledge of the Foundation’s constituent base, and inform fundraising, communications and financial strategies/activities with the goal of enhancing and strengthening the Foundation’s mission. The ideal candidate has the perfect mix of analytical know-how with the ability to present that information to non data end users – in other words, a “data-driven storyteller”.
As the Data Analyst, you’ll bring your analytics skills and business or marketing insights experience to help cultivate a data driven culture at CTF, by designing and delivering analytics solutions that make data analytics easier and more effective for stakeholders.
You will have a record of success in presenting complex data processes to non-data users, the skills to make informed recommendations based on data, and experience with improving data processes and pipelines. You will work closely with functional leaders, organizational units, and internal subject matter experts to identify, develop, and deploy actionable data activities in support of those processes and functions. This role will be instrumental in the ongoing development/improvement of CTF’s data platforms, including Salesforce CRM, Salesforce Marketing Cloud and Social Studio, as well as integrated platforms such as Classy and Intacct.
Read more: https://www.linkedin.com/jobs/view/3129476290/
Link:
https://www.linkedin.com/jobs/view/3129476290/
Postdoctoral Fellowship – Gene Therapy for Neurofibromatosis type 1 (NF1)
Massachusetts General Hospital
The Walker Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital (MGH), Harvard Medical School, is seeking highly motivated postdoctoral fellow candidates to join our enthusiastic diverse team to develop cutting-edge gene editing therapies for neurofibromatosis type 1 (NF1).
We use a combination of genetic, molecular, and biochemical approaches with both animal and human cell models to improve our mechanistic understanding of NF1 and identify therapeutic targets. The laboratory is located on the main MGH campus in downtown Boston, MA. MGH is the largest hospital-based research enterprise in the United States.
The new hire will be appointed as a Postdoctoral Fellow at MGH, with a joint appointment as a Research Fellow at Harvard Medical School and access to multiple educational and research resources. The Postdoctoral Fellow will play an integral role in projects to develop innovative gene editing strategies for NF1-associated tumors. The position will involve collaborations with other labs at MGH, Harvard Medical School, and other institutions. The position offers opportunities to co-mentor Research Technicians, graduate students, and student interns and ample opportunities to present research findings in scientific papers and at conferences.
The ideal candidate should have:
• A Ph.D. in Biology, Biochemistry, Genetics, Neuroscience, Genomics, or other closely related fields
• Strong proficiency in standard molecular biology techniques, experience with mammalian cell culture; familiarity with NGS methods and data analysis
• Experience with commonly used bioinformatics tools and databases, and other standard software
• Proven ability to work independently as well as part of a team in a fast-paced, highly collaborative, and supportive environment
• First (or co-first) author of one or more peer-reviewed scientific publications
• Excellent written and verbal communication skills, organizational skills and time-management
Link:
https://walkerlab.mgh.harvard.edu/positions-available/
Research technician
Johns Hopkins
Openings available for research technician. Johns Hopkins University. Lab manager position available.
Link:
None
Postdoctoral fellows and research assistants
Abigail Wexner Research Institute at Nationwide Children’s Hospital
To study NF2/Merlin biology and therapeutic development
Link:
None
Clinical Geneticist, Director of NF Clinic
Cincinnati Children's Hospital Medical Center
Cincinnati Children's Hospital Medical Center is recruiting an interested physician to lead our NF Clinic. The clinic provides care for approximately 1500+ individuals with Neurofibromatosis type 1 and related disorders (NFRD) along the lifespan. We work alongside multidisciplinary team members within Oncology, Neurology, Ophthalmology and Orthopedics, among others, with an expertise within these conditions. Clinical responsibilities would include providing care to our patient population, alongside two physicians and a nurse practitioner with expertise in NFRD as well as within multidisciplinary clinics. Our center has a robust history and infrastructure conducive to an academic career in both translational and clinical research, including clinical trials as well as longitudinal, historical data and prospective registry.
Link:
https://jobs.cincinnatichildrens.org/search/jobdetails/human-genetics-clinical-faculty-opportunity/74d03e5d-7dbf-4cf0-90bc-cd7b13ea0e96?utm_campaign=google_jobs_apply&utm_source=google_jobs_apply&utm_medium=organic
Audiology Clinic Education Coordinator
California State University, Sacramento
The Department of Communication Sciences and Disorders is seeking a Full-time Lecturer, Audiology Clinical Education Coordinator, with a potential Fall 2022 start date. This appointment will involve clinic coordination, supervision of students enrolled in the doctorate of audiology program, marketing and public relations work, and teaching at the University level.
This full-time, 12-month, temporary, non-tenure-track appointment, which is not a probationary position, will be for a three (3) year term and will terminate at the end of the 2024/25 academic year, and does not establish consideration for subsequent appointments or any further appointment rights. However, this lectureship may be renewed annually dependent upon satisfactory performance, curricular needs, student enrollment and budget consideration.
Link:
https://careers.csus.edu/en-us/job/506216/fulltime-lecturer-audiology-clinical-education-coordinator
Scientific Project Manager, Brain Tumor Initiative
Gilbert Family Foundation
The Scientific Project Manager is responsible for the overall management of projects, timelines, and deliverables for the Gilbert Family Foundation’s Brain Tumor Initiative. Using sound scientific judgement and understanding of BTI goals and objectives, the Scientific Project Manager provides oversight for all BTI projects and activities. The Scientific Project Manager represents BTI in the scientific community with professionalism and a deep understanding of the field and its challenges and is expected to actively engage with relevant communities to develop relationships and opportunities for collaboration and capacity building. The Scientific Project Manager reports to the Foundation’s Scientific Officer.
Link:
https://www.myrocketcareer.com/job-detail-page/14093913/scientific-project-manager-brain-tumor-initiative-remote-detroit-mi/
Scientific Analyst
Gilbert Family Foundation
The Scientific Analyst is an all-rounder role to support our small team achieve our mission of accelerating a cure for neurofibromatosis type 1 (NF1). The Scientific Analyst will serve as a Project Manager for several individual grants and provide support as needed to Scientific Project Managers for Curing NF research initiatives. The Scientific Analyst will also support new program and partnership development through evaluation of new funding opportunities and novel medical and healthcare technologies relevant to curing NF1.
Associate Biomedical Data Manager
Sage Bionetworks
We are seeking a Biomedical Data Manager to work in a team environment to support data sharing for large biomedical communities. The work includes the harmonization, analysis, and sharing of biomedical data (e.g., omics, clinical, and imaging data) across various biomedical research institutions. The ideal candidate will be enthusiastic about the application of technology to enable open, collaborative, and reproducible biomedical research.
Link:
https://sagebionetworks.org/careers/associate-biomedical-data-manager/
Biostatistician
Sage Bionetworks
Sage Bionetworks is seeking a data scientist with expertise in biostatistics who will participate in data coordination and data quality efforts across participating sites of an expanding international network. The data scientist will participate in retrospective clinical research project by working with data managers, researchers, project leadership, and strategic informatics partners. The candidate must be able to work both independently and in a team environment. The ideal candidate is an experienced and highly organized individual.
Link:
https://sagebionetworks.org/careers/biostatistician/
Research Technician I – Gene Therapy for Neurofibromatosis type 1 (NF1)
Massachusetts General Hospital
The Walker Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital (MGH), Harvard Medical School is seeking a highly motivated research technician to join our enthusiastic diverse team to develop cutting-edge therapies for neurofibromatosis type 1 (NF1).
We use a combination of genetic, molecular, and biochemical approaches with both animal and human cell models to improve our mechanistic understanding of NF1 and identify therapeutic targets. The laboratory is located on the main MGH campus in downtown Boston, MA. MGH is the largest hospital-based research enterprise in the
United States.
The Research Technician will assist in projects investigating disease mechanisms and discovery of therapeutic targets, as well as design and testing of potential novel treatments. Responsibilities will include: 1) Molecular cloning to generate CRISPR gene editing and transgenic constructs (DNA/RNA isolation and analysis, PCR, plasmid cloning, sequencing); 2) Human cell culture (including stem cells) and CRISPR/Cas9 gene editing experiments; 3) Analysis of signaling pathways (western blot analysis and ELISAs).
Opportunities include developing individual projects and contributing to high-profile publications as an author.
Requirements:
Bachelor’s degree in biology or related field is required. Research experience, either as a technician or undergraduate independent research project preferred, but not required. Must be self-motivated and able to work independently after training, with attention to detail and excellent verbal and written communication skills.
• Ability to work independently and as a team member
• Good communication skills
• Computer literacy
• Ability to perform multiple tasks independently
Link:
https://walkerlab.mgh.harvard.edu/positions-available/
Research Technician I – Drosophila Models of Neurological Disease
Massachusetts General Hospital
The Walker Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital (MGH), Harvard Medical School is seeking a highly motivated research technician to join our enthusiastic diverse team to help develop cutting-edge therapies for neurofibromatosis type 1 (NF1).
Our group focuses primarily on NF1, one of the most common inherited neurological disorders. We use a combination of genetic, molecular, and biochemical approaches with both animal and human cell models to improve our mechanistic understanding of NF1 and identify therapeutic targets. The laboratory is located on the main MGH campus in downtown Boston, MA. MGH is the largest hospital-based research enterprise in the United States.
The Research Technician will assist in projects investigating disease mechanisms and discovery of therapeutic targets, as well as design and testing of potential novel treatments. Responsibilities will include: 1) Maintenance of Drosophila stocks and genetic crosses; 2) Conducting neurobehavioral assays with Drosophila disease models; 3) Devising and testing candidate therapeutics in Drosophila.
Opportunities include developing individual projects and contributing to high-profile publications as an author.
Requirements:
Bachelor’s degree in biology or related field is required. Research experience, either as a technician or undergraduate independent research project preferred, but not required. Must be self-motivated and able to work independently after training, with attention to detail and excellent verbal and written communication skills.
• Ability to work independently and as a team member
• Good communication skills
• Computer literacy
• Ability to perform multiple tasks independently
Link:
https://walkerlab.mgh.harvard.edu/positions-available/
Postdoc
The Medical College of Wisconsin
Preclinical research on NF1-associated tumors using big data analysis, cell models, and mouse models.
Link:
https://fcd.mcw.edu/?faculty/view/name/Daochun_Sun_PhD/id/8533
Two NIH-funded postdoctoral research fellowship positions available to study Cancer Biology and Stem Cell Biology in NF1
University of Texas Southwestern Medical Center
Two NIH-funded postdoctoral research fellowship/research scientist positions are immediately available in Dr. Le’s laboratory in the Department of Dermatology and Simmons Comprehensive Cancer Center at UT Southwestern Medical Center to study Cancer Biology and Stem Cell Biology.
Our lab investigates how genetic and microenvironmental factors interplay to regulate tumorigenesis. Our research focuses on identification of the cell of origin and elucidating the role of tumor microenvironment in cancer development. We dissect the cellular and molecular mechanisms of carcinogenesis from a developmental perspective using Neurofibromatosis Type 1 (NF1), a common tumor predisposition human genetic disorder, as a model. While working on neurofibromatosis, our research group serendipitously uncovered the identity of follicular epithelial cells that directly give rise to hair and mechanisms that cause hair to turn gray – findings that led to our second focus to identify possible treatments for balding and hair graying associated with aging.
Our laboratory is a collaborative effort between the Department of Dermatology, the Cancer Center, the Hamon Center for Regenerative Science and Medicine, and the O’Donnell Brain Institute to offer an extraordinarily rich environment that encompasses both basic and translational research. Candidates must hold a Ph.D., M.D./Ph.D., or M.D. degree and should possess good communication skills.
Please see our recent publications at: Le Laboratory publications
Interested candidates should send an updated CV, with names and contact information of three professional references to:
Lu Q. Le, M.D., Ph.D.
Professor
Department of Dermatology
Simmons Comprehensive Cancer Center
Hamon Center for Regenerative Science and Medicine
O’Donnell Brain Institute
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX
75390-9069
email: lu.le@utsouthwestern.edu
Link:
https://www.utsouthwestern.edu/labs/le-lu-q/
Postdoc position
MD Anderson Cancer Center
Postdoctoral positions are available at the University of Texas MD Anderson Cancer Center. The successful appointee(s) will be working under the supervision and mentorship of Yuan Pan, PhD, Assistant Professor in the Department of Symptom Research.
We are a young lab looking for one or more highly motivated individuals with a strong interest in neuroscience and/or cancer biology. Our team studies the neuron-cancer and neuron-glia interactions in neurofibromatosis type 1 (NF1), a cancer predisposition syndrome. We use state-of-art neuromodulatory techniques, preclinical mouse models, primary cell culture, and molecular biology approaches to achieve these goals.
The postdoctoral fellow(s) will gain an understanding of neuronal regulation of nervous system cancer and glia-mediated neurological deficits. They will learn skillsets in neuroscience, cancer biology, cell biology, and molecular biology. Dr. Pan will guide the postdoctoral fellow(s) in study design, data analysis, interpretation, presentation, manuscript writing, and grant application.
An ideal candidate should have a doctoral degree, with a background in neuroscience, cancer biology, cell biology, molecular biology, genetics, or related fields.
Prior experience in mouse handling/surgeries and neuroscience approaches is highly desired. Experience in the following skillsets is preferred but not all required: tissue processing, cell culture, gene expression manipulation, microscopy, immunohistochemistry, qPCR, FACS, MACS, RNAseq. The postdoctoral fellow is expected to be highly motivated, dedicated, organized, and have excellent technical skills, communication skills, and a strong work ethic. The candidate is expected to be an excellent team player who can work together with others.
Interested candidates please apply via the link
Link:
https://www.postdocjobs.com/posting/7100817
Research Associate II
MD Anderson Cancer Center
We are seeking Research Associate II responsible for the following key roles
1. Plans and performs various experiments with mic to assess behaviors
2. Performs injections, surgeries, and other manipulations in mice.
3. Collects and processes tissues from mice for further analysis
4. Performs ELISA, Western blotting, PCR, immunohistochemistry, or other bench techniques as needed.
4. Records and evaluates data obtained in accordance with methods requested and reports the findings to the PI.
5. Coordinates ordering lab supplies.
6. Trains RA1, students and new members of the lab in animal handling and experiments
7. Other duties as assigned.
Interested candidates please apply via the link
Link:
https://jobs.mdanderson.org/search/jobdetails/research-assistant-t-ii---symptom-research-cao/29472638-e312-40c8-a79d-54129de690aa
Two Assistant Professor positions
Brody School of Medicine at East Carolina University
One tenure-track Assistant Professor position and one Research Assistant Professor position in the Department of Pharmacology & Toxicology at the Brody School of Medicine at East Carolina University.
Review of applications is just beginning. Please apply asap. Contact Ray Mattingly for more details.
Link:
https://jobs.sciencecareers.org/job/602780/-assistant-professor-965008/
Deciphering molecular signature of pre malignant lesions in NF1
Mondor Institute for Biomedical Research
We seek to hire a highly motivated postdoctoral fellow to work on exploring genetic, epigenetic and transcriptomic alterations driving malignant transformation in NF1. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with no effective therapy to date. Our team has developed a Nf1-KO mouse model that successfully recapitulates the development of pNFs and their transformation into MPNSTs through a dysplastic phase. This project aims to apply multi-omics approach on dNFs issued from this mouse model and from NF1 patients to address key questions concerning molecular events underlying malignant transformation of NFs. First, by performing biobanking followed by genetic, epigenetic and transcriptomic analyses of tumor cells we expect identifying molecular alterations and candidate genes involved in this process. Next, by grafting individually barcoded tumor cells into nude recipients, and analyzing developing tumors at successive transformation steps, we will rank these molecular modifications, and set up a patient-derived xenograft model for drug screening essays. Last, by grafting tumor cells carrying permanent inactivation of candidate genes, we expect to functionally validate their role in progression of dNFs into MPNSTs. The candidate will also participate in translational research aimed at using ex and in vivo models of malignant transformation to identify molecules capable of preventing or slowing this process.
The Postdoc candidate should have expertise in both cellular and molecular biology applied to cancer. A background in single cell molecular analyses (epigenetics and transcriptomics, coding in R), both experimental procedure and bioinformatic analysis would be appreciated but not required. The post-doc candidate will integrate our young and dynamic team including Postdocs, clinicians, engineers and PhD students
Link:
None
Several openings at Healx
Healx
At Healx, a drug discovery company that focuses on Rare Diseases based in Cambridge UK we have several job opportunities open:
-Cell biologists
-Computational System Biologists
-High Content Imaging Specialists
Please reach out to any of the Healx team present at the conference if you want to know more about the roles, our mission, and the company culture.
Thank you
Link:
https://healxstaging.wpengine.com/careers/
Lab manager / senior research specialist
Johns Hopkins
Lab manager / senior research specialist. Primary scientific responsibility relates to management of the JH NF Biospecimen repository, banking samples, maintaining database, and interacting with investigators both within and outside JH. Animal work required. Interacting with patients required.
Link:
https://jobs.jhu.edu/job-invite/81460/
