Scientist - Structural Biology
Takeda Pharmaceuticals
Takeda’s Structural Biology team within the Drug Discovery Sciences (DDS) department at Takeda is looking for a talented and enthusiastic Scientist I with a strong background in the performing high throughput structural biology and in the administration of the associated computer infrastructure. The candidate has an excellent track record at supporting and performing X-ray crystallography and may also have experience with cryo-EM.
The successful candidate will sustain and innovatively build upon a sophisticated crystallographic data processing pipeline, as well as liaise with external vendors to develop and implement our next-generation structure curation and storage solution. The candidate will have deep knowledge of Python and shell scripting in a Linux environment. As part of DDS, you will also collaborate closely with biophysicists, structural biologists, chemists, computational chemists, and biologists, and will work closely with project teams to advance small molecule drug discovery programs.
We are seeking an energetic and innovative individual that identifies and solves critical technical challenges, and thrives in multidisciplinary, science driven and highly innovative environments.
Link:
https://www.takedajobs.com/job/san-diego/scientist-structural-biology/1113/16181743952
cryoEM aplication scientist or developer
Single Particle LLC
cryoEM data processing specialist and methods development. Familiar with RELION and cryoSPARC algorithm and experience solving high resolution structures. Software development skills a plus.
Gene to Structure Pfizer, Groton CT, Very talented team
Pfizer
We are seeking an enthusiastic and driven postdoctoral fellow to join the Structural and Molecular Sciences (SMS) Department at the Pfizer campus in Groton, Connecticut. This fellowship offers the unique opportunity to learn about the drug and vaccine development process in the laboratories of an innovative industry leader. The successful candidate will receive state-of-the-art training in protein structural biology and biochemistry with access to unparalleled resources supporting prokaryotic and eukaryotic protein expression, purification, and structure determination by X-ray crystallography or cryo-EM. At SMS, we have regular access to all the major synchrotron beam lines in the world and dedicated in-house cryo-EM facilities. Ideal candidates will have experience in molecular biology, protein expression, protein purification, and structure determination.
ROLE RESPONSIBILITIES
Purification and assembly of challenging protein-protein, protein-RNA and protein-small molecule complexes
Iterative design and cloning to generate protein expression constructs
Determine the structure of a functional complex to by X-ray crystallography or cryo-EM
Structural analysis to generate and test hypotheses
Functional characterization of protein complexes by biophysical and biochemical methods
Collaboration across departments
Critical reading of the relevant literature
Manuscript preparation and presentation of results in oral and poster formats
BASIC QUALIFICATIONS
PhD in Structural Biology or Biochemistry with experience in the gene-to-structure pipeline
Construct design and molecular biology skills
Extensive experience in protein expression and purification
Experience with structure determination by X-ray crystallography and/or cryo-EM
Strong track record of publication in peer-reviewed scientific journals
Excellent verbal and written communication skills
PREFERRED QUALIFICATIONS
Experience in biophysical and biochemical assay development
Link:
https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/United-States---Connecticut---Groton/Postdoctoral-Fellowship-in-Structural-Biology-and-Biophysics_4816202
Field Application Scientist - West Coast
RedShiftBio
RedShiftBio is seeking a Field Applications Scientist, Western US to work with industrial and academic scientists to educate and train customers on the innovative AQS3 protein characterization system.
Additionally, you will work with customers to develop new protocols and methods specific to a customer’s research, feed product enhancements back to the internal product development teams, and promote our products and services through customer meetings, vendor shows, webinars, and national and international conferences and symposia.
Link:
https://redshiftbio.com/wp-content/uploads/2021/08/FieldAppsScientist_WestCoast.docx.pdf
Cryo-EM Center Director
Hauptman-Woodward Medical Research Institute
Hauptman-Woodward Medical Research Institute is seeking a Cryo-EM Center Director
The cryo-electron microscopy (cryo-EM) center at the Hauptman-Woodward Medical Research Institute (HWI) is a resource for academic and industrial users. The center features a Glacios 200 kV microscope with Falcon IV and CETA-D detectors, in a dedicated facility with a grid preparation laboratory, control room, and additional microscope rooms configured for growth. The cryo-EM center Director will be responsible for operational, scientific and strategic oversight, including growth of the facility and implementing a robust and reliable cryo-EM imaging pipeline. We have a broad spectrum of projects, from basic research to drug discovery, and users with a wide range of cryo-EM expertise. This is an Institute-supported position.
For more details, please visit https://hwi.buffalo.edu/cryo-em-center-director-position/ or contact Rory Curtis at rcurtis@hwi.buffalo.edu or 518-466-5418
Link:
None
MINFLUX-Postdoctoral Research Associate
Scripps Research
Hi! I recently received five years of funding (R01) for a postdoc to do some very cutting-edge research using the brand new MINFLUX light microscope at Scripps Research. This is a recent Nobel Prize winning technology that enables 1-3 nm spatial resolution using fluorescent light! It also offers sub-millisecond single molecule tracking in live cells.
Scripps currently has the ONLY scope available in the US! This makes almost anything done publishable since there has been very little biology completed at these resolutions in live systems. No other institute in the US currently has access to this technology.
We will study Natural Killer cell immune synapse structure in the context of HIV infection, particularly emphasizing mechanisms of ADCC activity. I am currently a Senior Staff Scientist in Andrew Ward’s lab, who will house the postdoc until I start my own faculty position (hoping in the greater San Diego Mesa area/Sorrento Valley area). This is a perfect chance to complement cryo-EM experience with expertise in super-resolution light microscopy, setting you up to be very valuable in the job market.
I am working on posting an official ad, but I wanted to give participants an early opportunity. A PhD is required but I can also leave the job open until the summer. Some experience with fluorescent microscopy is also highly desirable but not required.
If interested, please email me at cmurin@scripps.edu with your CV and we can set up a Zoom to chat more about the project and position. Also, referrals are most welcome!
Link:
None
Postdoctoral Research Associate
UC San Diego
POSTDOC POSITION DESCRIPTION
Applications are invited for a postdoctoral fellowship in The Skaggs School of Pharmacy & Pharmaceutical Sciences (SSPPS) in the Division of Health Sciences at UC San Diego.
SSPPS is committed to academic excellence and diversity within the faculty, staff, and student body. The school is ranked among leading pharmacy schools in its research endeavors and grant funding. SSPPS is based at the world-renowned La Jolla campus of UC San Diego with year-round access to both winter and summer recreational activities. UC San Diego Health System is the only academic medical center in San Diego providing leading-edge patient care, biomedical research, education and community service through two hospital locations and a network of outpatient facilities. SSPPS is committed to academic excellence and diversity within the academic, staff, and student body.
The Chang laboratory is located at SSPPS and has a focus on molecular structural biology using x-ray crystallography and now cryo-electron microscopy of several targets, including membrane proteins (transporters, channels, and receptors) and large molecular complexes. Understanding the mechanism of these proteins and their interactions will provide a detailed structural framework to understand their function(s).
Qualifications: This postdoctoral position will have emphasis on protein expression, purification, and molecular structure determination. Ideal candidates will have strong experience and expertise in protein expression systems (HEK, Sf9, Pichia pastoris, and bacteria), protein purification (affinity, ion exchange, size exclusion), and both of the aforementioned structural determination techniques (cryo-EM required).
Salary - Salary will be commensurate with qualification and experience.
Appointment Length/Period – up to five years with possibility for extension.
Review of applications will begin immediately and continue until the position is filled. Applicants should submit a cover letter,
