Postdoctoral Scientist - Chromatin in Normal and Malignant Hematopoiesis
Columbia University
Postdoctoral position available in the Viny Lab at Columbia University Irving Medical Center
A funded postdoctoral research associate position in the Viny lab is available immediately. Our laboratory studies epigenetic regulation in normal blood formation and in blood cancers. We aim to understand the role of altered chromatin architecture as a regulator of gene expression/gene silencing that maintain the balance of hematopoietic stem cell self-renewal with differentiation and blood formation. Employing new and existing mouse models, primary patient samples, and state-of-the-art epigenomic/transcriptional assays for assessing 3-dimensional chromatin structure in the malignant context. We aim to extend out studies of DNA architecture to determine its prognostic relevance and therapeutic potential in cancer.
The successful applicant will be part of a highly productive research team studying chromatin remodeling proteins and transcription factors in the context of cancer, with direct translational applicability. Applicants should be highly motivated and driven to study cancer epigenetics. The successful candidate will have the ability to think deeply about a problem and test it experimentally, demonstrate strong verbal and written communication skills, and is highly collaborative.
Interested candidates should send their CV and 1-2 letters of recommendation to: adv2105@cumc.columbia.edu
Link:
https://www.stemcell.columbia.edu/research-labs/viny-lab
Computational Scientist -
Columbia University
Computational biologist position available in the Viny Lab at Columbia University Irving Medical Center
A funded bioinformatics/computational scientist position in the Viny lab is available immediately. Our laboratory studies epigenetic regulation in normal blood formation and in blood cancers. We aim to understand the role of altered chromatin architecture as a regulator of gene expression/gene silencing that maintain the balance of hematopoietic stem cell self-renewal with differentiation and blood formation. Employing new and existing mouse models, primary patient samples, and state-of-the-art epigenomic/transcriptional assays for assessing 3-dimensional chromatin structure in the malignant context. We aim to extend out studies of DNA architecture to determine its prognostic relevance and therapeutic potential in cancer.
The successful applicant will be part of a highly productive research team studying chromatin remodeling proteins and transcription factors in the context of cancer, with direct translational applicability. Applicants should be highly motivated and driven to study cancer epigenetics. The successful candidate will have the ability to think deeply about a problem and test it experimentally, demonstrate strong verbal and written communication skills, and is highly collaborative.
Interested candidates should send their CV and 1-2 letters of recommendation to: adv2105@cumc.columbia.edu
Link:
https://www.stemcell.columbia.edu/research-labs/viny-lab
Postdoctoral position in the Bernstein lab (NYC)
Icahn School of Medicine at Mount Sinai
A funded postdoctoral research associate position in the Bernstein lab (https://labs.icahn.mssm.edu/bernsteinlab/) at the Icahn School of Medicine at Mount Sinai and Tisch Cancer Institute is available immediately. The Bernstein lab studies epigenetic regulation of gene expression and chromatin structure in cancer and development, with the long-term goal of understanding targetable chromatin changes in cancer.
The successful applicant will be part of a highly productive research team studying chromatin remodeling proteins and transcription factors in the context of cancer, with direct translational applicability. Applicants should be highly motivated and driven to study cancer epigenetics ideally with the following qualifications:
-Protein biochemistry including protein purification, mass spectrometry sample prep and data analysis, and protein immunoprecipitation
-Cell culture, CRISPR-mediated genomic editing, cancer-relevant cell phenotypic assays
-RNA-seq, CUT&RUN/ChIP-seq, ATAC-seq, and NGS analysis
-Ability to produce and handle large data sets and extract key information from them
-Bonus if experienced in drug or genomic screening (e.g. CRISPR screens)
The successful candidate will have the ability to think deeply about a problem and test it experimentally, demonstrate strong verbal and written communication skills, and be highly collaborative and a team player.
The successful candidate will be part of a thriving and diverse academic environment in the Department of Oncological Sciences within the Tisch Cancer Institute. The position offers competitive salary, subsidized postdoc-housing and exposure to a rich environment at Icahn School of Medicine at Mount Sinai and the New York City area. Interested candidates should send their CV and three letters of recommendation to: emily.bernstein@mssm.edu
PhD position in computational cancer research
Medical University of Graz
My lab is aiming at developing novel computational approaches for cancer research with a major focus on characterizing the molecular background of tumors across different omics levels and its evolution under therapy. We want to learn about mechanisms of treatment resistance and/or cancer recurrence and to stratify personalized treatment options. Our projects are motivated by actual clinical research questions and we work in a highly interactive environment with very close contact to clinicians and wet-lab researchers.
The PhD student will work on the integrative analysis of multiple molecular profiles of cancer patients including data from DNA- and RNA-sequencing, DNA methylation profiling, as well as clinical records.
Applicants should have a strong interest in cancer research and computational biology. Applicants must hold a Master’s degree (or equivalent) obtained in any related field such as bioinformatics/biology/medicine/mathematics/computer science/etc. Experience in analyzing omics data is a plus as well as experience in cancer research.
Postdoctoral Position - Epigenetic Alterations in the Pathology of Neurodegeneration
University of California San Diego
The Desplats Lab has a postdoctoral position open for immediate starting. The lab is interested in understanding how altered epigenetic mechanisms may contribute to adult neurodegenerative disorders, and we have a long-standing trajectory on unraveling disease mechanisms associated with alpha-synuclein misfolding and accumulation (PNAS 2009, 106(31): 13010-5; JBC 2012 287(38): 31691-702), including pioneering epigenetic analysis in Parkinson’s and Alzheimer’s diseases (Epigenetics 2013, 8(10): 1030; Alzheimers Dement. 2017 13(6):689-700; Epigenetics 2019, 14(4):365-382; Alzheimers Dement 2021, 13(1):e12156).
The study is based on modulation of DNA methylation in the context of neuroinflammation in Alzheimer’s disease, applying cellular and mouse models, CRISPR and Cre/flox tools, in addition to transcription and epigenetic analysis. Another aspect of the study is exploring epigenetic signals as biomarkers for diagnosis and disease progression, a highly-innovative and fast-paced project.
We are looking for a self-motivated individual with strong creative and critical thinking; detail-oriented and goal-driven researcher who is an exceptional team player.
Qualifications
• Recent Ph.D. in neurosciences, molecular or cell biology.
• Hands-on experience on cutting-edge technology for transcriptional and epigenetic analysis, like ChIP-seq; RNA-seq; ATAC-seq and similar techniques.
• Advanced skills in tissue culture, including gene modulation and CRISPR.
• Candidates with a proven record of proficient data analysis using complex bioinformatic pipelines will be prioritized.
• Expertise in mouse models of neurodegeneration, including stereotactic injections, brain sectioning and immunostaining.
• Excellent written communication skills and team-work.
Research Associate in Neurosciences (not postdoc)/Lab manager
University of California San Diego
Under supervision, this person will be responsible for carrying out experiments aimed at understanding the molecular mechanisms involved in neurodegeneration in Alzheimer's and Parkinson's diseases. The incumbent will perform tissue culture analysis, real time PCR, DNA methylation profiling, western blots, immunoprecipitation and cell assays. An important role in this position is maintaining the mouse colony, breeding, genotyping, performing minor surgeries, behavioral testing, drug administration and tissue collection. Basic managerial tasks will also be required, including general administration of the lab (arrange for equipment servicing; managing purchasing and documentation, maintaining updated records and compliance with EH&S and animal safety regulations.
Theoretical knowledge in cell biology, biochemistry, molecular biology and genetics.
Expertise in molecular biology including RNA/DNA isolation, real-time PCR, viral production, plasmid cloning and preparation.
Demonstrated experience with tissue culture, preferably with neuronal cell lines.
Experience in basic biochemistry methods, including Western blot, primary neuronal cultures, ELISA assay, immunohistochemistry and basic microscopy.
Hands-on experience in rodent models of disease, including colony management (breeding; genotyping, weaning), basic surgical procedures, drug delivery (i.p. injections), tissue collection (brain).
Link:
https://employment.ucsd.edu/111419-research-associate-neurosciences/job/17543675
