Scientific Software Developer (UCSD)
RCSB PDB
The RCSB PDB is seeking a Scientific Software Developer with skills as a seasoned, experienced bioinformatics programming professional and a broad understanding of computational algorithms.
The incumbent will develop, implement, and maintain complex scientific and web-based software systems for the RCSB Protein Data Bank (PDB; http://www.rcsb.org) at the University of California San Diego (UCSD).
The Scientific Software Developer will work closely and collaboratively with other software developers and scientists at the San Diego Supercomputer Center (SDSC) and the RCSB PDB partner sites to expand RCSB.org's functionality and reliability as a premier biological data and information resource. S/he will develop new scalable algorithms for the mining and analysis of the rapidly growing PDB archive using leading edge Big Data technologies, design and implement user interfaces for the query, analysis, reporting, and visualization of 3D structural information and associated annotations, as well as integrate external database resources with RCSB PDB to provide a structural view of biology. The incumbent will help lead the design of databases and data warehouses to store and aid in the query of data and be actively involved in the software development process, maintenance and system standards for analysis algorithms, tools, and infrastructure.
Additionally, the incumbent will serve as an expert on relevant scientific and technical aspects of the various web, web services, and database components of the RCSB PDB. S/he will stay abreast of the latest development in structural and computational biology and new technologies, apply advanced bioinformatics concepts to design, develop, modify, debug, and evaluate highly complex software programs and web tools, and translate scientific problems into scalable and maintainable software solutions that meet end-user needs. The incumbent will also further science through Scientific Publications, written in collaboration with our team.
Link:
https://www.rcsb.org/pages/jobs#sde
Postdoctoral Researcher (UCSD)
RCSB PDB-UCSD
We are seeking a talented, highly motivated postdoctoral researcher to join the multidisciplinary team of the RCSB Protein Data Bank at UC San Diego, San Diego Supercomputer Center (SDSC).
The successful applicant will work on research projects that drive next generation search tools at rcsb.org. Dealing with redundancy within the Protein Data Bank (PDB) is an important challenge in face of the ~10% year-on-year growth in structural data stored in the PDB. Tackling the redundancy problem requires understanding of similarities and differences among macromolecules at many different levels. She/he will be expected to contribute to this project by devising new and improved algorithms for protein family classification at levels such as biological assemblies. The ultimate aim of this project is to improve the findability of data in the PDB by building the next generation search engine for structural molecular biology.
Link:
https://www.rcsb.org/pages/jobs#postdoc
Scientific Web Application Developer (Rutgers)
RCSB PDB-Rutgers
We are looking for a highly motivated, full-stack developer with a minimum of five years experience using modern database and web technologies. The candidate should enjoy engaging with other developers and scientists in a collaborative team environment.
The work at RCSB PDB focuses on data analysis and transformation, and the presentation and visualization of data using complex interactive graphical user interfaces. An important aspect is to provide users with the ability to search and explore the PDB data archive. Solutions are implemented using a wide range of components developed and maintained in-house, in addition to third-party tools, libraries, frameworks and technologies. The candidate should be comfortable working in a fast-changing environment, and able to demonstrate an ability to think creatively, generate new ideas, and implement solutions. The candidate should also show an eagerness and willingness to learn new skills and technologies.
Link:
https://www.rcsb.org/pages/jobs#seniorweb
Postdoctoral researcher (UMass Medical School)
UMass Medical School
An NIH-funded postdoctoral position is available in the Department of Biochemistry and Molecular Pharmacology at the University of Massachusetts Medical School in Worcester, MA.
The Munson lab is elucidating the structure and function of regulators of intracellular membrane trafficking, including the exocyst complex, SNARE proteins and Sec1/Munc18 proteins. We are a multidisciplinary lab, using biochemical, structural, cell biological, microscopy and genetic studies in yeast, mammals and a variety of other eukaryotes with the goal of obtaining fundamental mechanistic understanding of the detailed regulation of exocytosis and endocytosis, and how dysfunction of this regulation impacts cellular biology and human disease.
Applicants must have (or expect to obtain shortly) a Ph.D. in Structural Biology, Biochemistry, Biophysics, or a related field. Previous hands-on experience with cryo-EM, protein biochemistry, purification, and analysis of protein-protein interactions is essential. In addition, experience with yeast genetics, protein crystallography, mass spectrometry, tissue culture, and/or fluorescence microscopy is preferred, but not required. The lab is highly collaborative, and strongly values and supports colleagues with diverse backgrounds and experiences. We are part of a dynamic structural biology and biochemistry community with outstanding resources, core facilities and training.
Link:
https://www.umassmed.edu/munsonlab/
POSTDOC – viral transcription-translation coupling
CEITEC MU (Central European Institute of Technology)
A postdoc position is available in newly established Demo lab (CEITEC, Masaryk University, Brno, Czech Republic) to participate in research focused on structural mechanisms of transcription-translation coupling
in virus-infected mammalian cells. We are seeking a person with expertise in molecular biology, biochemistry and virology, specifically in the field of dsDNA viruses and virus-infected mammalian cells
(to produce the viruses) and with some expertise in single-particle electron microscopy and cryo-electron tomography. Research will be conducted at CEITEC located in the life science campus of Masaryk
University (Brno, Bohunice, https://www.ceitec.eu/).eu/).
Requirements:
- PhD in virology/biochemistry or structural biology.
- Some years of work experience in preparation of samples for in vivo cryo-ET imaging and analysis of single-particle cryo-EM images and cryo-ET tomograms.
- Published in impactful journals in the field, corresponding to given stage of career demonstrating creativity and scientific quality
- Good English language – spoken and written
Desirable but not required:
- Motivated person with collaborative mind set
- Willingness to engage in the life of academic community
- [other, e.g. knowledge of particular techniques in given field]
We offer:
- Interesting position in a dynamically expanding research institute
- An attractive salary and benefits package
- Background of a recognized and successful institution with supportive and international working environment
- Environment promoting interdisciplinarity and intersectorality of research
- In house core facilities
- Support of administrative departments (including grant office service)
- Support with the relocation process (welcome office service)
- 6 weeks of paid holiday
Electronic application deadline is: 31st May, 2021
Applications including CV, contacts for referees and a brief motivation letter should be sent by e-mail to recruitment@ceitec.muni.cz.
Link:
https://www.ceitec.eu/postdoc-viral-transcription-translation-coupling/j255
POSTDOC – Cryo-EM and cryo-ET of bacterial and viral transcription-translation coupling
CEITEC MU (Central European Institute of Technology)
A postdoc position is available in the newly established Demo lab (CEITEC, Masaryk University, Brno, Czech Republic) to participate in research focused on structural mechanisms of transcription-translation coupling in bacteria and potentially in virus-infected mammalian cells. We are seeking a person with excellent expertise in single particle cryo-electron microscopy and cryo-electron tomography, specifically oriented on the imaging of in vitro assembled systems and bacterial or virus-infected mammalian cells. Research will be conducted at CEITEC located in the life science campus of Masaryk University (Brno, Bohunice, https://www.ceitec.eu/).
Requirements:
- PhD in biochemistry or structural biology.
- Excellent knowledge of single particle cryo-electron microscopy (cryo-EM) or cryo-electron tomography (cryo-ET).
- At least 2 years of work experience in preparation of samples for in vivo cryo-ET imaging and analysis of single-particle cryo-EM images and cryo-ET tomograms.
- Published in impactful journals in the field, corresponding to given stage of career demonstrating creativity and scientific quality
- Good English language – spoken and written.
Electronic application deadline is: 31st May, 2021
Applications including CV, contacts for referees and a brief motivation letter should be sent by e-mail to recruitment@ceitec.muni.cz.
Link:
https://www.ceitec.eu/postdoc-cryo-em-and-cryo-et-of-bacterial-and-viral-transcription-translation-coupling/j252
Postdoctoral fellow
Vanderbilt University
State of the art integrative structural biology (NMR, crystallography, SAXS, cryo EM, and modeling). Opportunities are also available to pursue fragment-based discovery of small molecule inhibitors of critical protein-protein interactions.
One program focuses on multi-domain proteins and multi-protein complexes involved in DNA replication, damage response, and repair. Project directed to discerning the structural mechanisms of DNA priming and replication fork reversal, as well as defining the roles of 4Fe-4S clusters and DNA charge transport in these processes [e.g. O’Brien et al., Science 355, 813 & eaag1789, 2017].
A second Program is directed to infectious disease and the innate response. These studies focus on the roles of calprotectin (CP) in nutritional immunity and in inflammation signaling via the receptor for advanced glycation end products (RAGE). The candidate will join a team carrying out highly inter-disciplinary research in collaboration with microbiologist Eric P. Skaar and many other laboratories at Vanderbilt and around the world. Studies include determining the structural mechanisms of CP activation of RAGE, and fragment-based discovery of small molecule inhibitors CP-RAGE interactions.
Job openings at the Bujnicki lab in Warsaw
The International Institute of Molecular and Cell Biology in Warsaw
Please have a look at our job openings.
We welcome applications from researchers at all career stages.
Link:
http://genesilico.pl/employment
CryoEM staff scientist
New York Structural Biology Center
The New York Structural Biology Center (NYSBC) seeks an electron microscopist to join the staff of the Simons Electron Microscopy Center (SEMC) (semc.nysbc.org). The facilities include 13 transmission electron microscopes (with seven Titan Krios instruments) and 2 dual-beam scanning electron microscopes equipped with cryo stages. This individual will primarily be a cryoEM specialist who will assist users of the facility to carry out service experiments and will also have the option to pursue collaborative research projects. The individual should be capable of multitasking, should enjoy working with other people, should have a good working knowledge of electron microscopes and a strong research background. Good communication skills are essential. Salary commensurate with experience.
Find detailed job responsibilities and qualifications on the JobRxiv posting.
Link:
https://jobrxiv.org/job/new-york-structural-biology-center-27778-cryoem-staff-scientist/
Expert in data management and scientific programming
Institute of Biotechnology
We are looking for an expert in scientific programming for the MOSBRI project (Molecular Scale Biophysics Research Infrastructure) with experience in scientific data processing for a European project focused on Standards for Data Archival and Exploitation.
We offer attractive work connected to development of data management infrastructure for biophysical data in the frame of an international project at the Institute of Biotechnology in the center of excellence Biocev. The main responsibility lies in definition of data standards and models for biophysical data, development of algorithms, design of user interface, and realization of a pilot database of biophysical data. The person is expected to actively participate in multilateral international negotiations, to drive the tasks fulfillment in collaboration with the local international partners, and to present the results.
Link:
https://www.mosbri.eu/
Postdoctoral Research Positions in Network Science and Complex Systems
Northwestern University
We are seeking motivated individuals with a strong quantitative background with a PhD in physics, mathematics, computer science, bioinformatics or a related field. The ideal candidate has experience in at least one of the following fields: renormalization group techniques, Monte Carlo methods, information theory, disordered systems, systems biology, neural networks or graph theory.
Current projects are centered around the following topics: link prediction and functional annotation in physical and functional biological networks, signed social networks, higher-order genetic and drug interactions, brain networks and other inter-cell communication networks, dynamics and evolution of large graphs, criticality in disordered systems and complex quantum networks.
We believe in diversity as a driving force of excellence. Therefore, we strongly encourage members of underrepresented groups to apply. The researchers will be appointed for one year (12 months) with the possibility to extend for up to three years, based on satisfactory performance. Applications will be accepted until the positions are filled. There are additional openings for postdoctoral researchers with external funding.
Those interested in these positions are encouraged to send their application
(i) a current CV with publication list,
(ii) a brief statement of research experience and interests, and
(iii) two letters of recommendation sent separately.
to Professor Istvan Kovacs in the Department of Physics and Astronomy, Northwestern University, Evanston: istvan.kovacs@northwestern.edu
Link:
https://physics.northwestern.edu/people/faculty/core-faculty/istv%C3%A1n-kov%C3%A1cs.html
Postdoctoral Associate Structural Biology and Molecular Biophysics
Rensselaer Polytechnic Institute
Our NIH-funded research program involves structural studies of viral protein - host protein complexes and integral membrane proteins (IMPs), that are targets for antimicrobial drug discovery. Projects involve structure-dynamic-function studies using integrative methods of bioinformatics, NMR spectroscopy, X-ray crystallography, small angle X-ray scattering (SAXS), cryoEM, and molecular modeling.
A successful candidate will have a Ph.D. in a field closely related to Structural Biology, and have experience using modern techniques of biomolecular NMR, SAXS, cryoEM, and/or X-ray crystallography, including crystallization, data collection, and/or structure analysis. Expertise in membrane protein biochemistry is highly desirable. Candidates with extensive experience in preparing IMPs but limited experience in structure determination are also encouraged to apply.
Link:
https://montelionelab.chem.rpi.edu/
Staff Scientist / Technician in Molecular Biology and Biochemistry
Rensselaer Polytechnic Institute
The Center for Biotechnology and Interdisciplinary Studies at Rensselaer Polytechnic Institute seeks a biochemist to work as a lab researcher in molecular biophysics and structural biology laboratories. Job responsibilities include assisting in studies involving the application of structural biology approaches to the problems of molecular biophysics and proteomics. The work entails construction of expression plasmids for novel genes from the human and other genomes, expression of such constructs in bacterial and yeast hosts, and purification and evaluation of the resultant recombinant proteins and nucleic acids. The successful candidate would have B.S., M.S. or Ph.D. in biochemistry or related field. They would collaborate with other team members to characterize biomolecules biochemically and biophysically, and prepare suitable quantities of these proteins for structural studies.
Link:
https://montelionelab.chem.rpi.edu
Senio Bio Engineer
Instadeep
InstaDeep is looking for a Senior Bio-Engineer to join our expanding team in London, UK. The Senior Bio-Engineer at InstaDeep develops software applications and data pipelines, in collaboration with other team members. In this role at InstaDeep you will report to the Bio Lead.
ROLE RESPONSIBILITIES/ACCOUNTABILITIES
• Design, implement and deliver complex pieces of research and engineering as part of a multi-functional Clinical Engineering team.
• Implement and evaluate cutting-edge machine learning algorithms over healthcare data.
• Manipulate and evaluate large and complex medical datasets with privacy constraints.
• Developing, and operating data integration pipelines to provide high quality datasets for analytical and machine learning use-cases.
• Coordinate with internal teams from local and international offices
• Create solid and self-explanatory documentation.
• Continuously improve our algorithms and approaches. On this note we encourage thinking outside the box and want our employees to challenge the status quo.
• Won’t do easy, and be inspired and proud of your work.
REQUIREMENTS
• Master's or PhD degree in BioInformatics or related area.
• Experience with machine learning in the biological / health domain
• Experience in structure modelling of proteins (PyMol, Rosetta, EVOF2, Gromacs or similar)
• Knowledge and experience working with handling PDB and mmcif files.
• Expert knowledge in areas around immunology, genomics, is advantageous
• Excellent written and verbal communication skills in English.
• Experience in communicating with users, other technical teams and management to collect requirements, identify tasks, provide estimates and meet production deadlines.
• Detective-level attention to detail and self-discipline that others would love.
• Experience with data features engineering, missing data
Link:
http://www.deepchain.bio
Postdoctoral Fellow
University of Texas at El Paso
Investigate the structure and function of modular polyketide synthase proteins that produce natural product antibiotics (X-ray crystallography and cryo-EM).
Link:
https://cyklab.org/
Postdoctoral Fellow
University of Nebraska-Lincoln
Investigation on the structure and mechanism of the metalloproteins in redox stress response and antibiotic resistance
Link:
https://biochem.unl.edu/limei-zhang
Postdoctoral Researcher
NINDS
A position is available for a Postdoctoral Researcher / Scientific Programmer with a PhD degree in Bioinformatics, Software Engineering, Computational Chemistry/Physics/ Biophysics and/or Mathematics. The successful candidate will be a member of the Computational Structural Biology Unit led by Dr. Lucy Forrest, in the National Institute of Neurological Disorders and Stroke, within the world-class National Institutes of Health Intramural Research program in Maryland USA, which provides a diverse and stimulating international environment. The project will involve the design and implementation of software applications specific to computational structural biology of membrane proteins, and/or their application to interesting problems in structural biology. Opportunities include development and testing of novel functionalities for existing software packages and databases relating to alignment of membrane protein primary sequences (AlignMe) and organization of their structures and symmetries (EncoMPASS).
The ideal candidate will be creative, conscientious, and demonstrate strong interpersonal skills and fluency in the English language. Demonstrated experience in programming is essential, knowledge of Python or C++ an advantage. Knowledge of Biochemistry and Structural Biology, particularly of membrane proteins, would be a strong advantage. Dr. Forrest is strongly committed to equal opportunity hiring for women and/or those from groups underrepresented in science, including persons of color, those with disabilities, and members of the LGBTQIA community. The position is available from September 2021 and will be held open until a suitable applicant is found. Interested parties should email Dr. Forrest at lucy.forrest@nih.gov, providing a cover letter, a CV, and a list of 3 people willing to provide recommendation letters. More information about the group is available at: www.forrestlab.org.
Postdoctoral Fellow
National Cancer Institute/NIH
Projects are described on the website and please feel free to contact us.
We use NMR, biophysics, and collaborate to use X-ray crystallography and cryoEM.
Link:
https://ccr.cancer.gov/center-for-structural-biology/r-andrew-byrd
