Proposition de thèse Ultrasons. iBrain Tours
Laboratoire INSERM U1253 Imagerie et cerveau
Mesure de l'élasticité et de la perfusion du cerveau et des tumeurs cérébrales par ultrasons et IRM.
Étudiant en M2 ou dernière année d'école d'Ingenieur. Compétence en Acoustique physique, biomécanique, traitement du signal.
Link:
None
Postdoc position
Aix Marseille University
We are seeking two highly motivated and committed candidates for 18-24-months, full-time postdoctoral positions at the SMARTc laboratory (CRCM, UMR Inserm U1068, CNRS UMR 7258) of the Aix Marseille University (AMU), Marseille, France.
The SMART c is interested in developing modelling & simulation tools to optimize anticancer therapies. Here, we are particularly interested in developing innovative adaptive dosing strategies, using state-of-the-art computational approaches in the field of cancer, as part of an A*MIDEX-funded project focusing on immunotherapy in lung cancer and a INCa –funded project focusing on pancreatic cancer.
Background in pharmacokinetics/pharmacodynamics (PK/PD), ideally in oncology, is suitable. Successful experience with population approaches and working knowledge of usual softwares (e.g., MatLab, Monolix, NonMem), coding languages (R, Python), and the ability to critically assess biological data, including PK/PD data, will be appreciated. Knowledge of contemporary mathematical methodologies applicable to modelling is required. The successful candidate will work collaboratively with other members of the laboratory (mathematicians, physicists, oncologists) to advance on-going projects, but must be able to work independently. Basic french is a plus.
A*MIDEX and INCa-funded salaries will be competitive and commensurate with qualifications and experience.
Please email your detailed CV including publication list with copies of the most relevant ones, and the names/contact information of two individuals/supervisors who can provide a detailed account of your accomplishments and abilities to:
Dr Joseph Ciccolini; SMARTc Unit - AMU; joseph.ciccolini@univ-amu.fr
ATER CNU 61-63
LISSI - CMC Créteil
Composante : UFR Sciences et Technologie
Laboratoire : LISSI
Identification de l’emploi publié
Nature de l’emploi : ATER
Poste n° : MCF 0894 N° de discipline CNU :61 -63
Etat du poste : Vacant
Date d’affectation : 01/09/2019
Profil du poste :
Enseignement :
Optimisation, Systèmes parallèles, Programmation orientée objet, Bases de Données en Master.
Electronique Numérique en Licence.
Recherche :
Le candidat effectura sa recherche au LISSI et devra possséder une expertise scientifique en analyse des données (image ou signal) via des méthodes d’apprentissage profond et d’optimisation stochastique.
Les applications ciblées concernent principalement l’analyse de données biomédicales pour l’aide au diagnostic médical.
Enseignement :
Lieu principal d’exercice (site, adresse, code postal) : CMC Créteil
61, avenue du Général de Gaulle 94010 CRETEIL CEDEX
Equipe pédagogique : Champ d’Electronique et Génie Informatique
Nom directeur département: Franck Monmasson
Email : monmasson@u-pec.fr
Tel. : 0145171493
Recherche :
Lieu principal d’exercice (site, adresse, code postal) : Site de VITRY
122, rue Paul Armangot 94400 VITRY-sur-Seine
Laboratoire d’accueil : Laboratoire Images, Signaux et Systèmes Intelligents (LISSI)
Nom du directeur du laboratoire : Yacine Amirat
Email : amirat@u-pec.fr
URL labo : http://www.lissi.fr/accueil/
Contact : Amir Nakib ; nakib@u-pec.fr
Patrick Siarry ; siarry@u-pec.fr
Nom du Directeur de la composante :
Jacques Moscovici
Courriel :
doyen.sciences@u-pec.fr
Secrétariat
0145171330
Link:
HTTP://www.lissi.fr/accueil
Post doc position
Institut Galien Paris Sud
In the framework of the European Project PANIPAC we are hiring a full-time post doc to investigate how nanotechnology could manipulate and/or reeducate the immune cells of the tumor microenvironment and locally deliver substances that can stimulate immunological responses. Successful delivery of nanoemulsions will be explored in vitro on a 3D pancreatic tumor model co-cultured with immune cells.
The candidate must hold a PhD, or obtain a PhD in the near future, should have solid experience in the areas of cell biology, immunology and/or tumor-microenvironment interactions as demonstrated by the publication record, including at least one first authorship.
Experience with formulation and characterization of drug delivery systems is also advantageous.
The candidate must be proficient in oral and written English. We are looking for candidates who have excellent communication skills, are team-oriented, driven, focused, self-motivated, trustworthy, critical and open-minded.
Link:
https://twitter.com/murasimona/status/1125302195585462273?s=21
Master2 internship
Institut Galien Paris-Sud
Pancreatic cancer is the 4th leading cause of cancer-related death in Europe and North America and shows a median survival of less than 6 months. With the aim to increase the therapeutic efficacy in pancreatic cancer a wide range of nanoscale drug delivery systems (i.e., nanomedicines) has been developed in the last decades. However, despite their potential efficiency, progresses in pancreatic cancer therapy have remained exceedingly slow mainly as consequence of an inefficient drug delivery to cancer cells. The extensive desmoplastic reaction is the hallmark of this tumor and acts as a physical barrier sequestrating nanomedicines, blocking their diffusion and limiting the effectiveness of the treatment. Thus, in vitro models, which reliably mimic the clinical conditions, are highly required for an appropriate preclinical screening of nanomedicines.
In this context, this research project aims to develop a tumor-on-a-chip as an innovative 3D in vitro model of pancreatic cancer able to recreate the complex physiology of the tumor microenvironment. Based on a microfabrication protocol well established at C2N, the student will first fabricate PDMS microfluidic-based platforms. These devices will be used at Institut Galien for spatially control a triple co-culture of Panc-1 tumor spheroids, fibroblasts and endothelial cells (HUVECs) embedded in fibrin-collagen hydrogels. The development of a perfusable microvascular network interconnected with a stroma barrier will allow shedding lights on the parameters which play a crucial role in the kinetic, diffusion and efficacy of the anticancer drugs. Attention will focus on chemical composition, size, shape and surface properties of nanomedicines. Information gathered by this complete screening will enable to identify the strategies that would prompt the penetration of the drug delivery systems in the tumor mass.
Link:
https://www.linkedin.com/pulse/nanoscreenchip-combining-3d-cell-culture-microfluidic-simona-mura/
