Jobs Posted on the Whova Community Board of RNA Canada 2024: The future of RNA technology
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Chemo-Enzymatic synthesis of glycoRNA/Synthèse chemico-enzymatique de glycoARN
National Research Council Récemment, des ARNs avec des glycans complexes (glycoARNs) ont été identifiés dans les cellules de mammifères. Ces glycoARNs sont des petits ARNs non-codants. Le rôle de ces moléc... ules biologiques n’est pas connu. Dans ce projet, l’équipe interdisciplinaire concevra des glycoARNs synthétiques qui seront produits par les membres chimistes du groupe. La personne retenue aura comme objectif de synthétiser de façon chemo-enzymatique des glycoARNs par des techniques standards de chimie de synthèse et de biochimie enzymatique (e.g. faire de la chromatographie sur couche mince, utiliser un rotovap, analyser un spectre RMN ou un spectre de masse et utiliser un HPLC).` Recently, RNAs with complex glycans (glycoRNAs) have been identified in mammalian cells. These glycoRNAs are small non-coding RNAs. The role of these biological molecules is not known. In this project, the interdisciplinary team will design synthetic glycoRNAs that will be produced by the chemist members of the group. The selected candidate will aim to chemo-enzymatically synthesize glycoRNAs using standard techniques in synthetic chemistry and enzymatic biochemistry (e.g., performing thin-layer chromatography, using a rotary evaporator, analyzing an NMR spectrum or a mass spectrum, and using HPLC).
Link:https://inrs.ca/les-etudes/projets-de-maitrise-et-de-doctorat/repertoire-des-projets-etudes/synthese-chemico-enzymatique-de-glycoarn/See More >>
PhD and Postdoctoral Positions in Bacterial Epitranscriptomics and Synthetic Biology
Max Planck Institute for terrestrial Microbbiology RNA’s simple chemical structure, composed of four nucleotides, contrasts with its highly complex functionality. Over 170 RNA modifications have been identified, impacting its func... tion and stability. The Höfer lab primarily focuses on characterizing RNAs modified at their 5' terminus with the redox factor nicotinamide adenine dinucleotide (NAD). Since the discovery of NAD-modified RNAs in 2015, they have been found in all kingdoms of life. Building on these findings, the Höfer lab aims to understand the functional role of NAD-RNA in model organisms such as Escherichia coli and bacteriophage T4. The lab's research integrates synthetic biology, biochemistry, chemistry, and bioinformatics to uncover the connections between redox biology, gene expression, and regulation. Recent discoveries, including enzymes responsible for NAD-RNA biosynthesis and removal, offer insights into NAD-RNA's biological significance e.g. regulating RNA stability. In 2023, the Höfer lab introduced the concept of RNAylation—how RNAs and proteins interact—which provides a new perspective on RNA functionality (Wolfram-Schauerte, Nature 2023). However, the broader biological roles of NAD-RNAs remain poorly understood. We look for candidates that would like to study the functional role on NAD-capped RNA in bacteria and bacteriophages or aim to apply the beauty of RNA-modifications in the field of synthetic biology.
The successful applicant should hold a degree in Molecular Biology, Biochemistry, or a related discipline.
The fellow will join a young, highly interactive, interdisciplinary and collaborative research team at the Max Planck Institute for Terrestrial Microbiology in Marburg, which is a world-leading hub of microbiology with state of the art research infrastructure and a highly stimulating intellectual environment.
Montreal Clinical Research Institute (IRCM) We are looking for a passionate manager to lead the development and operations of the RNA Therapeutics Platform at the Sidney-Altman Hub at IRCM.
You will play a central r... ole in the day-to-day management of operations and the execution of activities, ensuring a harmonious workflow and fostering collaboration between multidisciplinary teams. This position offers a unique opportunity to contribute to cutting-edge research on RNA therapies and to stimulate innovation in RNA biology.
See details for task, responsibilities, job requirements, benefits, and application info in the link below.
University of Alberta Join a cutting-edge project exploring non-DNA-based life at the University of Alberta! Work with a dynamic team on designing and modelling xenoriboses—novel sugars that could revo... lutionize synthetic biology and biotechnology. 🔹 Skills: Computational Biology, RNA Structure Prediction 🔹 Collaborate with leading experts! Apply now and help shape the future of life sciences! [see the ad]
Link:https://www.linkedin.com/posts/activity-7241528194858655746-Ursf?utm_source=share&utm_medium=member_iosSee More >>
PDF/PhD vaccine comparisons (bioinformatics)
University of Alberta Join our team at the cutting-edge of science! The COBRA Lab at the University of Alberta is hiring Postdoctoral Fellows and PhD students for a groundbreaking project in AI and mac... hine learning for vaccine development (PIVOT). Be part of a dynamic, multidisciplinary team working to optimize vaccine efficacy and safety through advanced AI models. Apply by November 15, 2024. Learn more and submit your application at jabbari@thecobralab.com Link:https://www.linkedin.com/posts/activity-7241871402302087168-d2Gl?utm_source=share&utm_medium=member_iosSee More >>
PDF/PhD saRNA vaccines (bioinformatics)
University of Alberta The COBRA Lab at the University of Alberta is hiring multiple Postdoc and PhD researchers to work on cutting-edge self-amplifying RNA (saRNA) vaccine development using AI & ma... chine learning. Join a dynamic team, collaborate with world-class experts like Nobel laureate Michael Houghton and CIFAR AI Chair Russ Greiner and help design next-gen vaccines for viral threats like Influenza, Lassa, and Orthopox viruses. If you’re passionate about structural RNA bioinformatics and global health security, apply by November 15, 2024!
Link:https://www.linkedin.com/posts/ugcPost-7244092890392526848-xTV7?utm_source=share&utm_medium=member_iosSee More >>
RNA Therapeutics Platform Technician
Montreal Clinical Research Institute (IRCM) We are looking for a passionate scientist to work on the development of RNA Therapeutics (mRNA-LNp, antisense oligos, siRNA, sgRNA) at the new RNA therapeutics Platform at the Mon... treal Clinical Research Institute (IRCM).
You will play a central role in the day-to-day operations and execution of activities, ensuring harmonious workflows and fostering collaboration between multidisciplinary teams. This position offers a unique opportunity to contribute to cutting-edge research on RNA therapies and to stimulate innovation in RNA biology.
Link:
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Post-doc: Immune response to glycoRNAs in mouse model
Institut national de la recheche scientifique (INRS) www.inrs.ca Recently, RNAs with complex glycans (glycoRNAs) were discovered in mammalian cells. These glycosylated RNAs are small, non-coding RNAs. Little is known about the biological role... s of these molecules. In this interdisciplinary project, the impact of glycosylation on the immune response to synthetic RNAs will be investigated in a mouse model. GlycoRNAs will be designed and produced by chemists on the team. The person selected for this position will then be responsible for testing the immune response to these RNAs in mice using techniques such as multiparametric flow cytometry and RT-qPCR among others.
Candidate profile: Candidates should hold a Ph.D. in immunology or a related field. They should have extensive experience in the design and interpretation of flow cytometry experiments, and with murine experimental models, as demonstrated in publications.
Research director: Prof. Angela Pearson This is a 2-year post-doctoral position (New Frontiers Research Fund grant). $52 000/year taxable ________ Récemment, des ARNs avec des glycans complexes (glycoARNs) ont été identifiés dans les cellules de mammifères. Ces glycoARNs sont des petits ARNs non codants. Le rôle de ces molécules biologiques est peu connu. Dans ce projet, l’équipe interdisciplinaire concevra des glycoARNs synthétiques qui seront produits par les membres chimistes du groupe. La personne retenue aura comme objectif de caractériser la réponse immunitaire à ces glycoARNs dans un modèle murin par des techniques standards de cytométrie en flux et de RT-qPCR, entre autres.
Profile recherché : Être titulaire d’un Ph.D. en immunologie ou un domaine connexe. Posséder des habiletés techniques en cytométrie en flux et en modèles murins démontrées dans des publications.
Direction : Pre Angela Pearson Le financement de ce projet post-doctoral est prévu pour une période de 2 ans (subvention Nouvelles frontières en recherche). $52 000/an imposable
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Postdoctoral Research Associate in RNA Biochemistry
University of Notre Dame Opening for a Postdoctoral Research Associate at the University of Notre Dame
The DasGupta Laboratory in the Department of Chemistry and Biochemistry at the University of N... otre Dame is looking to recruit a Postdoc in RNA biochemistry. We are a young lab trying to reconstruct the origins of RNA-based cellular life using a wide range of approaches including, but not restricted to, in vitro RNA evolution, structural biology, RNA enzymology, and synthetic cell research. We are also interested in understanding the fundamental mechanisms underlying RNA evolution. We are developing RNA-based tools to interrogate frontier problems in RNA biology such as transcriptomics of terminally-modified RNAs. Therefore, our lab straddles both extinct and extant RNA Worlds.
Interested candidates should email Saurja at sdasgupta@nd.edu with:
1 - A cover letter describing your research experience and interest. Please highlight any complementary skills you have. Don’t hesitate to be creative and propose potential projects.
2- A detailed CV listing your technical skills, publications, and contact information for three references (References will be contacted later).
Candidates with expertise in one or more of the following areas are encouraged to apply: Nucleic acid chemistry and biochemistry (RNA experience preferred), In vitro selection/Directed evolution of nucleic acids, X-ray crystallography, Bioinformatics, Synthetic cell/Protocell work.
We are a collaborative group, where you will get opportunities to mentor undergrad and grad students. We will support your career goals, whatever they may look like. The University of Notre Dame provides a close-knit, highly collaborative environment to expand your scientific horizons. You will get exciting opportunities to participate in events hosted by the Chicagoland RNA club and the University of Chicago Center for the Origins of Life.
Postdoctoral position to study RNP topology and disease
Université de Montréal The Zenklusen laboratory is looking for a motivated postdoc to investigate RNP topology, and the role of RNP topology in RNA metabolism; with the aim of establishing a mechanistic... understanding of how disrupting RNP topology and composition results in complex disease phenotypes. The project will employ multidisciplinary approaches in the areas of single-molecule and super-resolution microscopy, RNA/protein biochemistry, genomics and CRISPR-Cas9-mediated genome editing using mammalian cell culture models. Our lab focuses on advancing the understanding of gene regulation by developing and applying single-cell and single-molecule approaches, combined with biochemistry, genomic, proteomic, and computational methods to fundamental questions in RNA biology (Adivarahan et al., Mol Cell 2018; Bensidoun et al., Mol Cell 2022; Jayabalan et al., 2021; PNAS; Lessard et al., Nature Cell Biology 2018). We are located at the Department of Biochemistry and Molecular Medicine of the Université de Montréal, in Montreal, Canada, one of the most vibrant cities in North America and home to a strong RNA research community. Postdoctoral candidates must hold a PhD in biochemistry, biophysics, cell biology, computational biology or a related field. Motivation, creativity, independence and ability to interact with colleagues and collaborators should be among your core strengths when working with us. Interested applicants should email a CV and letter of introduction including the completion/ expected completion date of their PhD studies, proposed start date, a list of publications, names of three references who may be contacted for letters, and a brief description of future research interests to daniel.r.zenklusen@umontreal.ca.
University of Lethbridge Grad student positions starting summer 2025 on rRNA modification and oxidation, origin of life, ribosome engineering, synthetic biology, cell-free protein synthesis, bacterial str... ain engineering and more! Details in link
Link:https://www.linkedin.com/feed/update/urn:li:ugcPost:7246530172491874304/See More >>
Postdoctoral fellow/viral non-coding RNA in nuclear speckles
Jennifer Corcoran’s lab, University of Calgary We are a molecular virology lab that studies a viral non-coding RNA called kaposin. We recently discovered that kaposin, previously appreciated for its protein coding ability, is ... an architectural lncRNA that rebuilds nuclear speckles proximal to the DNA genome of the virus, KSHV, to optimize viral gene expression. Kaposin is the first RNA, cellular or viral, that is sufficient to recruit nuclear speckles to its site of transcription to regulate gene expression in cis. Please read the preprint link below and come to poster 202 if interested. PhD degree in molecular virology or RNA biology required.
PhD student/viral non-coding RNA in nuclear speckles
Jennifer Corcoran’s lab, University of Calgary We are a molecular virology lab that studies a viral non-coding RNA called kaposin. We recently discovered that kaposin, previously appreciated for its protein coding ability, is ... an architectural lncRNA that rebuilds nuclear speckles proximal to the DNA genome of the virus, KSHV, to optimize viral gene expression. Kaposin is the first RNA, cellular or viral, that is sufficient to recruit nuclear speckles to its site of transcription to regulate gene expression in cis. Please read the preprint link below and come to poster 202 if interested. MSC degree in molecular virology or RNA biology required.
Join “The Laboratory for RNA-Based Lifeforms” in University of Toronto’s Donnelly Centre. Together with Dr. Artem Bab... aian the work will develop the state of the art for the detection and sequence analysis of RNA viruses and virus-like agents.
Building upon the Serratus project (www.serratus.io) we will explore the fringes of Earth’s Virome. We developed an open-source cloud computing architecture to analyze 5.7 million sequencing datasets (10.2 petabases); discovering >130,000 novel RNA viruses (only 15,000 were known previously)… in only 11 days. Learn more in our first Nature paper [nature.com/articles/s41586-021-04332-2].
Today we're continuing the search, pushing to discover 100 million RNA viruses by 2030, and prioritizing which ones are pathogens causing human disease.
UConn Health TENURE-TRACK FACULTY POSITION IN GENETICS AND GENOMICS The Department of Genetics and Genome Sciences at UConn Health in Farmington, CT is inviting applications for a tenure-tr... ack faculty positions at the Assistant, Associate, or Full Professor level. Successful applicants will have the opportunity to participate in a highly interactive culture within the Department, our colleagues at the Jackson Laboratory for Genomic Medicine, and the UConn Institute for Systems Genomics. Successful candidates would be consummate team players in a highly interdisciplinary environment that brings together clinicians, biologists, molecular geneticists, and computational scientists. The ideal candidate is expected to complement existing strengths in the department with a robust research program focused on a cutting-edge area of contemporary genetics and/or genomics. Areas of particular interest include, but are not limited to single-cell genomics, RNA genomics, epigenetics, genome editing and engineering, synthetic genomics, genome technology, and computational genomics. The successful candidate will train students and postdoctoral fellows. The candidate will have access to outstanding core facilities including those that support single-cell genomics, DNA sequencing, high performance computing, microscopy, stem cell biology and FACS sorting. Minimum qualifications: PhD in an appropriate field, postdoctoral experience, and an outstanding record of research accomplishments. A demonstrated ability to secure external researchfunding and publish impactful peer-reviewed papers is expected. Applicants should apply at http://jobs.uchc.edu position number 2025-219 with a CV, cover letter and concise statements of research and teaching interests. In addition, applicants should arrange to have three letters of reference sent to Dr. Brenton Graveley at genetics@uchc.edu as a PDF document on letterhead with signature. Applications will be continuously reviewed until the positions are filled.
Link:
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Lehigh University The Department of Biological Sciences at Lehigh University invites applications for a tenure-track faculty position at the level of Assistant Professor in Genomics broadly defined... , effective July 2025.
Candidates must hold a Ph.D. in biology or a related field at the time of employment.
Within a multidisciplinary, collaborative research environment in the department and across the university, the successful candidate is expected to develop an internationally recognized, extramurally funded research program, participate in the department’s Ph.D. program in biology, and contribute to the department’s excellence in instruction and training of graduate and undergraduate students. We expect that the successful candidate will have a research program that complements the current research in the department.
Founded in 1865, Lehigh University has combined outstanding academic and learning opportunities with leadership in fostering innovative research. Recognized among the nation’s highly ranked research universities, Lehigh offers a rigorous academic community for over 7,500 students. Lehigh University has some 5,800 undergraduates, 1,800 graduate students, and nearly 600 full-time faculty members. Lehigh University is located in Bethlehem, PA., a vibrant and historic area near New York City and Philadelphia. Lehigh is committed to being an institution that strives to enhance diversity, inclusion and equity.
To apply, please submit: (1) a cover letter, (2) curriculum vitae, (3) research statement, (4) teaching statement, (5) a statement of contributions to diversity, equity, and inclusion, and (6) have at least three letters of recommendation submitted to: https://academicjobsonline.org/ajo/jobs/28345
For additional information contact Dr. Michael Layden, Chair, Genomics Search Committee at inbios@lehigh.edu or by mail at 111 Research Drive, Bethlehem, PA 18015.
crchum, Universite de Montreal we work on RNA binding proteins and the neurodegenerative diseases amyotrophic lateral sclerosis and frontal temporal dementia. we use a combination of cell culture models includi... ng ipscs mice and human material.
Link:www.vandeveldelab.comSee More >>
UBC Faculty position in Nucleic Acid Based Nanomedicine
Associate Professor (Tenure) or Professor (Tenure)| Departments of Biochemistry & Molecular Biology and Chemical & Biological Engineering
UBC Reporting to the Heads of BMB and CHBE, the successful candidate is expected to establish a field-defining research and training program that merges principles and techniques of b... iochemistry/molecular biology and engineering at the forefront of nanomedicines and cellular therapeutics. The successful candidate is expected to concentrate on addressing emerging needs in diverse areas such as vaccine development, or treatment of cancer, blood disorders, or genetic diseases. Demonstrating significant achievements in delivering groundbreaking advancements and leading a high-impact research program, along with effectively educating and mentoring future leaders in the specified field, is a key expectation for this position. The successful candidate will assume a leadership role within UBC’s nanomedicine initiative. They will be expected to capitalize on and contribute to resources and initiatives available at the university that foster the advancement of nanomedicines, such as NanoCore and the RNA Core. NanoCore offers expertise in lipid nanoparticle (LNP) design and manufacturing, established by Dr. Peter Cullis for the NanoMedicines Innovation Network (NMIN). The RNA Core provides high-quality custom RNA to both academic and industrial researchers on demand.
Link:https://ubc.wd10.myworkdayjobs.com/en-US/ubcfacultyjobs/job/UBC-Vancouver-Campus---Vancouver-BC-Canada/Faculty-position-in-Nucleic-Acid-Based-Nanomedicine_JR18439?q=biochemistrySee More >>
Scientist/Project Lead
Chinese Academy of Medical Sciences The Suzhou Institute of Systems Medicine （苏州系统医学研究所）is seeking a passionate and talented Scientist/Project Leader with expertise in RNA research. Join our cutting-edge team and le... ad projects that drive scientific discovery and innovation in the field of RNA.
Key Responsibilities: - Lead and manage RNA research projects in collaboration with internal and external stakeholders. - Design and execute experiments, analyze data, and contribute to the development of innovative RNA-based technologies. - Supervise junior researchers and collaborate with multidisciplinary teams. - Publish high-impact research papers and present findings at conferences.
Basic Qualifications: - PhD in Molecular Biology, Biochemistry, or related fields. - Strong scientific background and hands-on experience in RNA research techniques.
Preferred Qualifications (Bonus Points): - Extensive experience in RNA biology, including RNA delivery, RNA therapies, or mRNA technologies. - A track record of high-quality publications in relevant journals. - Passion for RNA research, with a proactive approach to solving scientific challenges.
Compensation: - Competitive salary: ¥500,000 - ¥600,000 RMB in the first year, with potential for performance-based bonuses. - Opportunities for career growth and professional development.
Join us and contribute to impactful RNA research at the forefront of molecular medicine!
Link:
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